Ībhilash L, Shindey R, Sharma VK (2017) To be or not to be rhythmic? A review of studies on organisms inhabiting constant environments. Collectively, these results provide a genome-wide insight into clock gene evolution in vertebrates.Ībhilash L, Sharma VK (2016) On the relevance of using laboratory selection to study the adaptive value of circadian clocks. We also performed a dN/dS analysis, and the results suggest that clock1 and clock2 may show distinct fates for duplicated genes between the lobe-finned and ray-finned fish clades. Moreover, protein sequence comparisons indicate that CLOCK protein changes among vertebrates were concentrated at the N-terminal and poly Q regions. Interestingly, we discovered that osteoglossomorph fishes possess two clock2 genes. The following syntenic analysis confirmed that clock1a, clock1b, and clock2 are conserved in teleost species. However, the majority of teleosts possess three clock genes (two clock1 genes and one clock2 gene) owing to extra whole-genome duplication. In lobe-finned fishes and some basal non-teleost ray-finned fishes, only two clock isotypes were found ( clock1 and clock2). Using genome-wide analysis, we extracted 264 clock sequences. ![]() Here, we aimed to elucidate the evolutionary history of the clock gene family in a taxonomically diverse set of vertebrates, providing novel insights into the evolution of the clock gene family based on 102 vertebrate genomes. Circadian locomotor output cycle kaput ( Clock), the most critical gene in the circadian rhythm feedback system, plays an important role in the regulation of biological rhythms. Circadian rhythms not only influence the overall daily routine of organisms but also directly affect life activities to varying degrees.
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